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Adele Lehane

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AsPr Adele Lehane

 https://orcid.org/0000-0002-0050-9101
20042026

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  • Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

    Awalt, J. K., Ooi, Z. K., Ashton, T. D., Mansouri, M., Calic, P. P. S., Zhou, Q., Vasanthan, S., Lee, S., Loi, K., Jarman, K. E., Penington, J. S., Qiu, D., Zhang, X., Lehane, A. M., Mao, E. Y., Gancheva, M. R., Wilson, D. W., Giannangelo, C., MacRaild, C. A. & Creek, D. J. & 21 others, Yeo, T., Sheth, T., Fidock, D. A., Churchyard, A., Baum, J., Famodimu, M. T., Delves, M. J., Kristan, M., Stewart, L., Sutherland, C. J., Coyle, R., Jagoe, H., Lee, M. C. S., Chowdury, M., de Koning-Ward, T. F., Baud, D., Brand, S., Jackson, P. F., Cowman, A. F., Dans, M. G. & Sleebs, B. E., 24 Apr 2025, In: Journal of Medicinal Chemistry. 68, 8, p. 8933-8966 34 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • A pH Fingerprint Assay to Identify Inhibitors of Multiple Validated and Potential Antimalarial Drug Targets

    Lindblom, J. C. R., Zhang, X. & Lehane, A. M., 18 Mar 2024, In: ACS Infectious Diseases. 10, 4, p. 1185-1200 16 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    9 Citations (Scopus)

  • Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides

    Redway, A., Spry, C., Brown, A., Wiedemann, U., Fathoni, I., Garnie, L. F., Qiu, D., Egan, T. J., Lehane, A. M., Jackson, Y., Saliba, K. J. & Downer-Riley, N., Aug 2024, In: International Journal for Parasitology: Drugs and Drug Resistance. 25, 100536.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Citations (Scopus)

  • Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4

    Ashton, T. D., Calic, P. P. S., Dans, M. G., Kang Ooi, Z., Zhou, Q., Loi, K., Jarman, K. E., Palandri, J., Qiu, D., Lehane, A. M., Maity, B., De, N., Famodimu, M. T., Delves, M. J., Mao, E. Y., Gancheva, M. R., Wilson, D. W., Chowdury, M., de Koning-Ward, T. F. & Baud, D. & 4 others, Brand, S., Jackson, P. F., Cowman, A. F. & Sleebs, B. E., 2024, In: ChemMedChem. 19, 24, 16 p., e202400549.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    4 Citations (Scopus)

  • Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4

    Ashton, T. D., Calic, P. P. S., Dans, M. G., Ooi, Z. K., Zhou, Q., Palandri, J., Loi, K., Jarman, K. E., Qiu, D., Lehane, A. M., Maity, B. C., De, N., Giannangelo, C., MacRaild, C. A., Creek, D. J., Mao, E. Y., Gancheva, M. R., Wilson, D. W., Chowdury, M. & de Koning-Ward, T. F. & 9 others, Famodimu, M. T., Delves, M. J., Pollard, H., Sutherland, C. J., Baud, D., Brand, S., Jackson, P. F., Cowman, A. F. & Sleebs, B. E., 12 Aug 2024, In: Journal of Medicinal Chemistry. 67, 16, p. 14493-14523 31 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    7 Citations (Scopus)
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