Personal profile
Biography
Anne Brüstle is a group leader in the Division of Immunology and Infectious Diseases at the John Curtin School of Medical Research, Australian National University in Canberra.
Her work centres around the autoimmune component of Multiple Sclerosis, the most common neurodegenerative condition in young adults. Her group investigates key immune populations driving the pathogenesis of this devastating condition using laboratory model systems to understand the underlying biological principals. In collaboration with diverse industrial partners her group further evaluates potential new targets for conceptually novel MS treatments and deciphers their biological mechanisms in neuroinflammation. In 2018 she was awarded the Young Tall Poppy Award for her work for and with the MS community and she holds a senior research fellowship from MS Australia. She further is the MS research lead and chair of “Our Health in Our Hands” an transdisciplinary program to develop personalised monitoring and managing approaches for chronic autoimmune conditions such as MS and diabetes.
Anne completed her PhD in Human Biology 2008 at the Institute of Medical Microbiology, Philipps-University in Marburg, Germany. She was recruited to ANU in mid 2014, after being a post-doctoral fellow at the University of Toronto, Canada. Besides her research and MS community engagement she currently is Associate Dean HDR for the College of Health and Medicine.
Qualifications
PhD
Research student supervision
- Registered to supervise
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Collaborations and top research areas from the last five years
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Advanced immunophenotyping of lymphocyte and monocyte subsets in healthy Australian adults using a novel spectral flow cytometry panel
Davies, A. R., Kwong, K., Yu, Z., Diamand, K. E. M., Li, F.-J., Kannitha, L., Ali, S. A., Amjadipour, A., Padarin, A.-M., Devoy, M., Vohra, H., Miraghazadeh, B., Jiang, S. H., Brüstle, A., Cherbuin, N., Nolan, C. J., Cook, M. C., Gardiner, E. E., Read, S. & McNaughton, E. & 1 others, , 22 Jul 2025, In: Frontiers in Immunology. Volume 16 - 2025, 22 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Acceptability and Feasibility of the English Version of Elevida, a Self-Guided Online Fatigue Intervention for People With Multiple Sclerosis
Lane, J., Poyser, C., Zhao, Y., Lucas, R., Meyer, B., Heesen, C., Cherbuin, N., Bruestle, A., Macqueen, S., Richardson, A., Lueck, C. & Gold, S., Dec 2024, In: International Journal of MS Care. p. 347 354 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Cognitive Function Is Associated with the Genetically Determined Efficiency of DNA Repair Mechanisms
Cherbuin, N., Patel, H., Walsh, E. I., Ambikairajah, A., Burns, R., Brüstle, A. & Rasmussen, L. J., Feb 2024, In: Genes. 15, 2, 15 p., 153.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency
IRF4 International Consortium, Jan 2023, In: Science immunology. 8, 79, eade7953.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
Immunity against Moraxella catarrhalis requires guanylate-binding proteins and caspase-11-NLRP3 inflammasomes
Enosi Tuipulotu, D., Feng, S., Pandey, A., Zhao, A., Ngo, C., Mathur, A., Lee, J., Shen, C., Fox, D., Xue, Y., Kay, C., Kirkby, M., Lo Pilato, J., Kaakoush, N. O., Webb, D., Rug, M., Robertson, A. A. B., Tessema, M. B., Pang, S. & Degrandi, D. & 9 others, , 10 Feb 2023, In: EMBO Journal. 42, 6, p. e112558 e112558.Research output: Contribution to journal › Article › peer-review
Open Access29 Citations (Scopus)
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Investigating the phenotype and functions of CD10- Neutrophlis in MS
Bruestle, A. (PI)
1/01/25 → 31/12/27
Project: Research
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Fatigue In Relapsing Multiple Sclerosis-Epstein Barr Virus (EBV) Treatment Trial (FIRMS-EBV)
Bruestle, A. (PI), Hardy, T. (PI), Hardy, T. (PI), Barton, J. (CoI), Butzkueven, H. (CoI), Gaudieri, S. (CoI), Giovannoni, G. (CoI), Kilpatrick, T. J. (CoI), Lloyd, A. (CoI), Monif, M. (CoI), Parratt, J. (CoI), Phan, T. G. (CoI), Ponsonby, A.-L. (CoI), Potter, A. (CoI), Spelman, T. (CoI), Vucic, O. (CoI) & Vucic, O. (CoI)
28/08/24 → 28/08/29
Project: Research
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Applying OCCAMS molecular razor to study the role of EBV in MS pathogenesis
Bruestle, A. (PI), Phan, T. (PI), Andrews, T. (CoI), Ballouz, S. (CoI), Deenick, E. (CoI), Desborough, J. (CoI), Goodnow, C. C. (CoI), Hewitt, A. (CoI), Jackson, K. J. L. (CoI), John, N. A. (CoI), Massey, J. (CoI), Palendira, U. (CoI), Parnell, G. P. (CoI), Parnell, G. P. (CoI), Tscharke, D. (CoI), Yazar, S. (CoI) & Zaunders, J. J. (CoI)
16/08/24 → 31/05/27
Project: Research
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Accredited Cytokine Testing and Deep Immunophenotyping Facility
Randall, K. (PI), Bruestle, A. (CoI), Davies, A. (CoI), Desborough, J. (CoI) & Nolan, C. (CoI)
30/06/24 → 2/03/28
Project: Research
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MS Australia Senior Fellowship: Utilising the innate immune system to improve monitoring and treatment development in Multiple Sclerosis
Bruestle, A. (PI)
1/01/24 → 31/12/28
Project: Research