Research output per year
Research output per year
Personal profile
Biography
I am a group leader at the Eccles Institute of Neuroscience, JCSMR. I studied medicine in Shiraz University and received my PhD in Physiology from the Adelaide University in 2015. My research has focused on the physiological and pathological role of transient receptor potential channels (TRPs) in the mammalian cortex. TRPs comprise a superfamily of nonselective cation channels that are well preserved throughout evolution and across species from yeasts to humans.
Recently, my research identified high expression of TRP Ankyrin 1 (TRPA1) in rodent cortical neurons. Currently, I combine in vivo and in vitro electrophysiology, two-photon calcium imaging, and behavioural assays to investigate how TRPA1 modulates sensory processing in rodent cortex across modalities of whisker-touch and vision. We expand this knowledge to understand the role of TRP channels in brain pathologies such as Multiple Sclerosis and Epilepsy.
Qualifications
MD, PhD
Research Interests
I am interested in studying the physiological and pathological role of Transient Receptor Potential (TRP) channels in rodent cortex.
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Collaborations and top research areas from the last five years
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Expectation violations enhance neuronal encoding of sensory information in mouse primary visual cortex
Tang, M. F., Kheradpezhouh, E., Lee, C. C. Y., Dickinson, J. E., Mattingley, J. B. & Arabzadeh, E., Dec 2023, In: Nature Communications. 14, 1, 1196.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus) -
A protocol for simultaneous in vivo juxtacellular electrophysiology and local pharmacological manipulation in mouse cortex
Kheradpezhouh, E., Mishra, W. & Arabzadeh, E., 19 Mar 2021, In: STAR Protocols. 2, 1, 100317.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Enhanced Sensory Coding in Mouse Vibrissal and Visual Cortex through TRPA1
Kheradpezhouh, E., Tang, M. F., Mattingley, J. B. & Arabzadeh, E., 21 Jul 2020, In: Cell Reports. 32, 3, 107935.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus) -
State-Dependent Changes in Perception and Coding in the Mouse Somatosensory Cortex
Lee, C. C. Y., Kheradpezhouh, E., Diamond, M. E. & Arabzadeh, E., 29 Sept 2020, In: Cell Reports. 32, 13, 108197.Research output: Contribution to journal › Article › peer-review
Open Access22 Citations (Scopus) -
Localized two-photon photoswitching of Optovin in rat cortical neurons
Kheradpezhouh, E., Choy, J. M. C., Arabzadeh, E. & Daria, V. R., 12 Apr 2019, In: Journal Physics D: Applied Physics. 52, 25, 254001.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus)
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The contribution of cortical TRPA1 to sensory perception and behaviour of mammalians
Kheradpezhouh, E. & Lee, C.
1/01/20 → 31/12/23
Project: Research