Personal profile
Biography
Qualifications
PhD in Mathematics
Research Interests
I am interested in numerical simulation, approximation, and statistical learning techniques. In particular I study the intersection of high dimensional approximation theory and high dimensional statistics. In a sense some of what I do is computational statistics. I like to develop algorithms and figure out where they work, why they work, and how they work (mathematically speaking, of course).
I have broad experience in the mathematical and computational disciplines. I started out as a quantitative analyst at a major investment bank. Following that my PhD was in quasi-Monte Carlo, which is a collection of methods for generating sample points in extremely high dimensional domains (a common problem in stochastic simulation, *ahem* as encountered for example at an investment bank...).
For a while I drifted to other numerical methods for stochastic processes, in particular non-Markovian random walks. That's when I got interested in applications to simulation of biological processes. The random walks of small particles in electrostatically trapping environments, for example pathogens in mucosal tissue, typically show non-Markovian behaviour. This can be suprisingly computationally intensive to simulate.
Since then I've returned to my true calling, high dimensions. In particular, approximation in high dimensions, and the variety of links to statistical learning problems in high dimension. In general, high dimensional problems are intractably hard, however most high dimensional problems we encounter hide some sort of structure that makes them emminently tractable to approximation algorithms.
Many "high dimensional" functions are really quite easy to integrate or approximate because of the high degree of smoothness they exhibit. This is typical for example of functions that come from mathematical finance or from parametric PDE problems. The trick is showing exactly when such desirable properties hold, and when they can be exploited.
A similar thing happens in high dimensional statistics. If we are given data with many attributes (e.g. personal data with height, weight, eye color, favourite Bee Gees song and many more fields...) that data is already high dimensional. However! There are dependencies. Correlations. There might be nonlinear correlations. The data might live on a very low dimensional manifold.
Research student supervision
- Registered to supervise
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Collaborations and top research areas from the last five years
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Protein evolution as a complex system
Gall, B., Pulsford, S. B., Matthews, D. S., Spence, M. A., Kaczmarski, J. A., Chen, J., Sandhu, M., Stone, E. A., Nichols, J. & Jackson, C. J., Sept 2025, In: Nature Chemical Biology. 21, 9, p. 1293-1299 7 p.Research output: Contribution to journal › Editorial › peer-review
1 Citation (Scopus) -
Leveraging ancestral sequence reconstruction for protein representation learning
Matthews, D. S., Spence, M. A., Mater, A. C., Nichols, J., Pulsford, S. B., Sandhu, M., Kaczmarski, J. A., Miton, C. M., Tokuriki, N. & Jackson, C. J., Dec 2024, In: Nature Machine Intelligence. 6, 12, p. 1542-1555 14 p., 1914.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Coarse reduced model selection for nonlinear state estimation
Nichols, J., 2022, In: ANZIAM Journal. 62, p. C192 -C207Research output: Contribution to journal › Article › peer-review
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Nonlinear Reduced Models for State and Parameter Estimation
Cohen, A., Dahmen, W., Mula, O. & Nichols, J., 2022, In: SIAM-ASA Journal on Uncertainty Quantification. 10, 1, p. 227-267 41 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Citations (Scopus) -
A general framework for fractional order compartment models
Angstmann, C. N., Erickson, A. M., Henry, B. I., McGann, A. V., Murray, J. M. & Nichols, J. A., 2021, In: SIAM Review. 63, 2, p. 375-392 18 p.Research output: Contribution to journal › Article › peer-review
Open Access45 Citations (Scopus)