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Biography
Dr Jon Roco is a biomedical research scientist with a diverse academic background that includes experimental immunology, bioinformatics, and statistics. He holds a PhD in Medical Sciences from The Australian National University, where his research focused on B cell biology and antibody responses. As a Postdoctoral Research Fellow, Dr. Roco expanded his research interests to precision medicine and how bioinformatics and single-cell technologies can be applied to analyse and understand the molecular basis of autoimmunity and immune deficiencies in humans.
Now, as a clinical trial biostatistician, his primary focus lies on the application of statistical methods to generate reliable evidence from clinical trials, ensuring these are conducted rigorously, ethically, and with statistical and experimental validity.
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Collaborations and top research areas from the last five years
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A TNIP1-driven systemic autoimmune disorder with elevated IgG4
Medhavy, A., Athanasopoulos, V., Bassett, K., He, Y., Stanley, M., Enosi Tuipulotu, D., Cappello, J., Brown, G. J., Gonzalez-Figueroa, P., Turnbull, C., Shanmuganandam, S., Tummala, P., Hart, G., Lea-Henry, T., Wang, H., Nambadan, S., Shen, Q., Roco, J. A., Burgio, G. & Wu, P. & 11 others, , Sept 2024, In: Nature Immunology. 25, 9, p. 1678-1691 14 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Zeb2 drives the formation of CD11c+ atypical B cells to sustain germinal centers that control persistent infection
Gao, X., Shen, Q., Roco, J. A., Dalton, B., Frith, K., Mee Ling Munier, C., Ballard, F. D., Wang, K., Kelly, H. G., Nekrasov, M., He, J.-S., Jaeger, R., Carreira, P., Ellyard, J. I., Beattie, L., Enders, A., Cook, M. C., Zaunders, J. J. & Cockburn, I. A., 29 Mar 2024, In: Science immunology. 9, 93, 17 p., eadj4748.Research output: Contribution to journal › Article › peer-review
42 Citations (Scopus) -
Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation
Chen, Z., Cui, Y., Yao, Y., Liu, B., Yunis, J., Gao, X., Wang, N., Cañete, P. F., Tuong, Z. K., Sun, H., Wang, H., Yang, S., Wang, R., Leong, Y. A., Davis, D. S., Qin, J., Liang, K., Deng, J., Wang, C. K. & Huang, Y. H. & 10 others, , Feb 2023, In: Science immunology. 8, 80, eadd1728.Research output: Contribution to journal › Article › peer-review
43 Citations (Scopus) -
Extrafollicular Plasmablasts Present in the Acute Phase of Infections Express High Levels of PD-L1 and Are Able to Limit T Cell Response
Serrán, M. G., Vernengo, F. F., Almada, L., Beccaria, C. G., Gazzoni, Y., Canete, P. F., Roco, J. A., Boari, J. T., Ramello, M. C., Wehrens, E., Cai, Y., Zuniga, E. I., Montes, C. L., Cockburn, I. A., Rodriguez, E. V. A., Vinuesa, C. G. & Gruppi, A., 16 May 2022, In: Frontiers in Immunology. 13, 828734.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
TLR7 gain-of-function genetic variation causes human lupus
Brown, G. J., Cañete, P. F., Wang, H., Medhavy, A., Bones, J., Roco, J. A., He, Y., Qin, Y., Cappello, J., Ellyard, J. I., Bassett, K., Shen, Q., Burgio, G., Zhang, Y., Turnbull, C., Meng, X., Wu, P., Cho, E., Miosge, L. A. & Andrews, T. D. & 24 others, , 12 May 2022, In: Nature. 605, 7909, p. 349-356 8 p.Research output: Contribution to journal › Article › peer-review
Open Access433 Citations (Scopus)