Personal profile
Biography
I am an early career postdoctoral researcher investigating neurodegenerative diseases and neuroinflammation. My PhD at La Trobe University focused on understanding how extracellular vesicles (EVs), small particles involved in intercellular communication, play a role in propagating neurodegenerative diseases through alterations in protein and miRNA cargo. Throughout my PhD studies, I successfully isolated EVs from human post-mortem brain tissue samples, serum samples, and cell culture supernatants. I became well versed in miRNA next generation sequencing and analysis, digital and RT-PCR, and proteomics analysis including identification of post-translational modifications. Furthermore, through animal studies characterizing the role EVs play in facilitating ALS, I was able to become proficient in working with animal models. I recently joined the Clear Vision Research Group at the Australian National University where I will continue researching the role of neuroinflammation in neurodegenerative diseases. I hope to identify protein post translational modifications induced through neuroinflammation and their effect on the pathogenesis and progression of neurodegeneration.
Qualifications
PhD
Research Interests
Neurodegeneration
Neuroinflammation
Post-translational modifications
Proteomics
Research student supervision
- Registered to supervise
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Collaborations and top research areas from the last five years
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A Panel of miRNA Biomarkers Common to Serum and Brain-Derived Extracellular Vesicles Identified in Mouse Model of Amyotrophic Lateral Sclerosis
Vassileff, N., Spiers, J. G., Lee, J. D., Woodruff, T. M., Ebrahimie, E., Mohammadi Dehcheshmeh, M., Hill, A. F. & Cheng, L., Aug 2024, In: Molecular Neurobiology. 61, 8, p. 5901-5915 15 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus) -
Neuroinflammatory Modulation of Extracellular Vesicle Biogenesis and Cargo Loading
Spiers, J. G., Vassileff, N. & Hill, A. F., Dec 2022, In: NeuroMolecular Medicine. 24, 4, p. 385-391 7 p.Research output: Contribution to journal › Review article › peer-review
Open Access16 Citations (Scopus) -
Inflammatory-Mediated Neuron-Glia Communication Modulates ALS Pathophysiology
Juliani, J., Vassileff, N. & Spiers, J., 2021, In: Journal of Neuroscience. 41, 6, p. 1142-1144Research output: Contribution to journal › Article
8 Citations (Scopus) -
Extracellular vesicles - Propagators of neuropathology and sources of potential biomarkers and therapeutics for neurodegenerative diseases
Vassileff, N., Cheng, L. & Hill, A. F., Dec 2020, In: Journal of Cell Science. 133, 23, jcs243139.Research output: Contribution to journal › Review article › peer-review
Open Access58 Citations (Scopus) -
Revealing the Proteome of Motor Cortex Derived Extracellular Vesicles Isolated from Amyotrophic Lateral Sclerosis Human Postmortem Tissues
Vassileff, N., Vella, L. J., Rajapaksha, H., Shambrook, M., Kenari, A. N., McLean, C., Hill, A. F. & Cheng, L., 16 Jul 2020, In: Cells. 9, 7, 1760.Research output: Contribution to journal › Article › peer-review
Open Access36 Citations (Scopus)