Research output per year
Research output per year
Personal profile
Qualifications
PhD in Medical Sciences | Immunology
BSc in Biotechnology | Biomedical Science
Biography
Dr. Paula Gonzalez-Figueroa is a Research Fellow at the Clinical Hub for Interventional Research (CHOIR) in the College of Health and Medicine at ANU. She holds a degree in Biotechnology and earned a PhD in Medical Sciences from The Australian National University. Her postdoctoral research, conducted at The John Curtin School of Medical Research at ANU and the Francis Crick Institute in the UK, focused on the regulation of B cell responses by follicular regulatory T cells (Tfr), particularly the role of Tfr-derived neuritin in controlling pathogenic antibodies. Discoveries in fundamental B cell and T cell biology from her research have led to the ongoing development of a neuritin-based biotherapeutic for allergy and autoimmune diseases.
As a Fellow at CHOIR, she has expanded her translational research interests to include clinical trial development. She is currently leading the design of a preclinical and Phase I clinical program for hematological cancers.
Research Interests
- Immunology
- Autoimmunity and Allergy
- Germinal Centres
- Regulatory T cells
- Plasma cells
- Clinical Research
- Preclinical drug testing platforms
- Early-phase clinical trial design and development
- Biomarkers in autoimmunity and cancer
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Collaborations and top research areas from the last five years
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Follicular regulatory T cells produce neuritin to regulate B cells
Gonzalez-Figueroa, P., Roco, J. A., Papa, I., Núñez Villacís, L., Stanley, M., Linterman, M. A., Dent, A., Canete, P. F. & Vinuesa, C. G., 1 Apr 2021, In: Cell. 184, 7, p. 1775-1789.e19Research output: Contribution to journal › Article › peer-review
Open Access98 Citations (Scopus) -
Class-Switch Recombination Occurs Infrequently in Germinal Centers
Roco, J. A., Mesin, L., Binder, S. C., Nefzger, C., Gonzalez-Figueroa, P., Canete, P. F., Ellyard, J., Shen, Q., Robert, P. A., Cappello, J., Vohra, H., Zhang, Y., Nowosad, C. R., Schiepers, A., Corcoran, L. M., Toellner, K. M., Polo, J. M., Meyer-Hermann, M., Victora, G. D. & Vinuesa, C. G., 20 Aug 2019, In: Immunity. 51, 2, p. 337-350.e7Research output: Contribution to journal › Article › peer-review
Open Access329 Citations (Scopus) -
A TNIP1-driven systemic autoimmune disorder with elevated IgG4
Medhavy, A., Athanasopoulos, V., Bassett, K., He, Y., Stanley, M., Enosi Tuipulotu, D., Cappello, J., Brown, G. J., Gonzalez-Figueroa, P., Turnbull, C., Shanmuganandam, S., Tummala, P., Hart, G., Lea-Henry, T., Wang, H., Nambadan, S., Shen, Q., Roco, J. A., Burgio, G., Wu, P., & 11 others, Sept 2024, In: Nature Immunology. 25, 9, p. 1678-1691 14 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in thebonemarrow
Elias, S., Sharma, R., Schizas, M., Valdez, I., Rampersaud, S., Park, S. M., Gonzalez-Figueroa, P., Li, Q. Z., Hoyos, B. & Rudensky, A. Y., 2022, In: Journal of Experimental Medicine. 219, 7, e20220047.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Regulatory roles of IL-10-producing human follicular T cells
Cañete, P. F., Sweet, R. A., Gonzalez-Figueroa, P., Papa, I., Ohkura, N., Bolton, H., Roco, J. A., Cuenca, M., Bassett, K. J., Sayin, I., Barry, E., Lopez, A., Canaday, D. H., Meyer-Hermann, M., Doglioni, C., De St Groth, B. F., Sakaguchi, S., Cook, M. C. & Vinuesa, C. G., 1 Aug 2019, In: Journal of Experimental Medicine. 216, 8, p. 1843-1856 14 p.Research output: Contribution to journal › Article › peer-review
Open Access67 Citations (Scopus)