Personal profile
Biography
I was awarded my PhD in protein biochemistry from Flinders University in April 2010. My doctoral work was carried out in the laboratory of A/Prof Peter Anderson, School of Biological Sciences, and involved the use of protein biochemistry to understand the activation mechanisms of plant innate immune receptors.
After completing my PhD in 2010 I took up a postdoctoral research fellow position at the University of Queensland (UQ) working with Professor of Structural Biology, ARC Laureate Fellow, Bostjan Kobe. In this role, I led the laboratory’s plant-microbe interactions research program for approximately 6.5 years.
In 2015, I was awarded a Discovery Early Career Research Award (DECRA) from the Australian Research Council to join the Research School of Biology (RSB) at ANU. in April 2016 I joined Professor Peter Solomon's group within the RSB to utilise protein biochemistry, structural biology and plant biology techniques to understanding how effector proteins from necrotrophic fungi cause disease in wheat.
In July 2018, I was employed as a lab leader, via a competitive recruitment process, in the Division of Plant Sciences, RSB, ANU. In October 2018, I was awarded an ANU Futures Scheme grant to support the establishment of my own laboratory and research program. In July 2020, I was awarded a prestigious ARC Future Fellowship aimed at understanding the molecular basis of fungal rust diseases in plants.
The Williams Plant Structural Immunology research laboratory is positioned within the Plant Microbe Interaction theme, Division of Plant Science in RSB. We utilise structural biology, protein biochemistry and synthetic biology approaches to study fungal pathogenesis and plant immunity.
Please see the below links for further access to publications. For free-access to our recent publication McCombe, Wegner et al in Science please access via this link https://www.science.org/stoken/author-tokens/ST-2473/full
Qualifications
PhD, BBiotech(Hons)
Research Interests
Structural Biology / Synthetic Biology / Plant-Microbe Interactions / Plant Innate Immunity / Fungal Pathogenesis
External Scholarly Memberships and Affiliations
Senior Editor – Molecular Plant Microbe Interactions
1 Jan 2023 → …
Research student supervision
- Registered to supervise
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Collaborations and top research areas from the last five years
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Identification of a Key Gain-of-Function Residue for Effector Binding by In Vitro Shuffling of Barley Mla NLR Genes
Zhang, X., Dagvadorj, B., Gao, J., Molloy, L. M., Crean, L. M., Williams, S. J. & Rathjen, J. P., May 2025, In: Molecular Plant-Microbe Interactions. 38, 3, p. 454-462 9 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Plant pathogenic fungi hijack phosphate signaling with conserved enzymatic effectors
McCombe, C. L., Wegner, A., Wirtz, L., Zamora, C. S., Casanova, F., Aditya, S., Greenwood, J. R., de Paula, S., England, E., Shang, S., Ericsson, D. J., Oliveira-Garcia, E., Williams, S. J. & Schaffrath, U., Feb 2025, In: Science (New York, N.Y.). 387, 6737, p. 955-962 8 p.Research output: Contribution to journal › Article › peer-review
28 Citations (Scopus) -
Revisiting the Evolution and Function of NIP2 Paralogues in the Rhynchosporium Spp. Complex
Darma, R., Yu, D. S., Outram, M. A., Ovenden, B., Sung, Y. C., Hill, E. H., Croll, D., Williams, S. J., Zhang, X., Milgate, A., Solomon, P. S. & McDonald, M. C., 19 May 2025, (E-pub ahead of print) In: Plant Pathology. 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
AvrSr27 is a zinc-bound effector with a modular structure important for immune recognition
Outram, M. A., Chen, J., Li, Z., Aditya, S., Tasneem, N., Arndell, T., Blundell, C., Ericsson, D. J., Figueroa, M., Sperschneider, J., Dodds, P. N. & Williams, S. J., 2024, (Accepted/In press) In: New Phytologist. 243, p. 314-329Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
Cyanobacterial α-carboxysome carbonic anhydrase is allosterically regulated by the Rubisco substrate RuBP
Pulsford, S. B., Outram, M. A., Förster, B., Rhodes, T., Williams, S. J., Badger, M. R., Price, G. D., Jackson, C. J. & Long, B. M., May 2024, In: Science advances. 10, 19, adk7283.Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus)
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Establishing transient assays to rapidly assess resistance responses in canola and test engineered resistance receptors for improved backleg resistance
Greenwood, J. (PI) & Williams, S. (CoI)
1/01/26 → 31/01/29
Project: Research
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Understanding the structural basis of the interaction between a pathogenicfungal effector and wheat resistance protein
Cross, E. (PI) & Williams, S. (CoI)
1/10/25 → 31/12/26
Project: Research
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Resurrecting defeated resistance genes to Septoria tritici blotch
Solomon, P. (PI) & Williams, S. (CoI)
23/05/25 → 23/11/26
Project: Research
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Characterisation of a novel disease immunity pathway in plants
Solomon, P. (PI) & Williams, S. (CoI)
11/09/24 → 10/09/27
Project: Research
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Dissecting the molecular basis of disease and resistance to Septoria tritici blotch
Solomon, P. (PI), McDonald, M. (CoI) & Williams, S. (CoI)
1/07/23 → 30/06/27
Project: Research