Personal profile
Qualifications
Commonwealth Scientific and Industrial Research Organisation - Business Development (Entrepreneurial and Small Business Operations)
Harvard Med Sch/Mass General Hospital -Postdoctoral (Biomedicine)
Uni of St Andrews- PhD (Optics, Biophysics)
Nanyang Technological University - B.Eng w Hons (Electronics)
Research Interests
- Interferometry
- Biological Physics
- Biofluidics
- Optical Imaging
Biography
Steve earned his doctorate in optics and biophysics from the University of St Andrews and subsequently expanded his expertise into biomedicine during a postdoctoral fellowship at Harvard Medical School. Since joining ANU in 2013, he has been instrumental in building the institution's capacity in biomedical imaging and optical biophysics. As head of the Optical BIofluidic Group (O-BIG), his research utilizes optical and fluidic technologies to investigate single cells responses to extracellular factors to form functional tissues, with a primary focus on advancing the production of biological tissue substitutes. His accomplishments in research and translation have been acknowledged with over 35 talks (invited, keynote) and awards, including Australian Museum Eureka Prize (ANSTO Innovative Use of Technology), an ARC Discovery Early Career Award and Royal Society Incoming Fellowship (UK).
Over the last decade, Steve’s team operates at the nexus of advanced imaging and biological physics with a motto to “invent new optical techniques to precisely quantify the fundamental functions of biological systems and discover new biological physics.”
Current research is to leverage multiscale, label-free imaging tools to quantitate how fluid dynamics and chemical ligands work cooperatively to drive cell communities to upregulate Cell Adhesion Molecules (CAM) and self-organize into cohesive, living tissues. The research advances the science of multicellularity by demonstrating how a subtle range of diverse combinations of biofluidic forces complements biochemical signals in promoting multicellularity. The outcomes of this research aim to benefit tissue and biomaterial engineering, as well as the invention of new imaging technologies. The imaging technologies are currently being commercialized by Ability Optics Pty Ltd (CSIRO On Accelerator 9).
External Scholarly Memberships and Affiliations
Scientific Advisory Board, ACRF Centre for Intravital Imaging of Niches for Cancer Immune Therapy
2024 → …
Associate Editor, American Institute of Physics
2024 → …
Editorial Advisory Board, AIP Biomicrofluidics
2023 → …
Editorial Advisory Board, APL Machine Learning
2023 → …
Scientific Director, Ability Optics Pty Ltd
2023 → …
Research student supervision
- Registered to supervise
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Using rotational integration of oblique interferometric scattering to track axial spatiotemporal responses of tubular membrane protrusions
Liu, J., Lim, Y. J., Herrmann, D., Timpson, P., Phan, T. G., Delghingaro Augusto, V., Parish, C., Liu, H., Guo, M. & Lee, W. M., Dec 2026, In: Nature Communications. 17, 1, 12 p., 4064.Research output: Contribution to journal › Article › peer-review
Open Access -
Combining multi-site FRAP and HILO-TIRF microscopy using a spatial light modulator
Upadhya, A., Lim, D. & Lee, W. M., 2025, In: Optics Express. 33, 21, p. 43676-43686 11 p.Research output: Contribution to journal › Article › peer-review
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Minimally invasive longitudinal intravital imaging of cellular dynamics in intact long bone
Bhattacharyya, N. D., Kyaw, W., McDonald, M. M., Dhenni, R., Grootveld, A. K., Xiao, Y., Chai, R., Khoo, W. H., Danserau, L. C., Sergio, C. M., Timpson, P., Lee, W. M., Croucher, P. I. & Phan, T. G., Dec 2023, In: Nature Protocols. 18, 12, p. 3856-3880 25 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Advanced optical holographic imaging technologies
Anand, V., Tahara, T. & Lee, W. M., Nov 2022, In: Applied Physics B: Lasers and Optics. 128, 11, 3 p., 198.Research output: Contribution to journal › Editorial › peer-review
Open Access3 Citations (Scopus) -
Computational single-objective scanning light sheet (cSOLS)
Xu, T., Lin, H., Lim, Y. J., Nicovich, P. R., Gaus, K. & Lee, W. M., 1 Aug 2022, In: APL Photonics. 7, 8, 081302.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus)
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5D Imaging Flow Cytometry for in vivo Quantification of Biological Fluids
Lee, S. (PI) & Gardiner, E. (CoI)
1/04/20 → 31/12/23
Project: Research
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ACRF Centre for Intravital Imaging of Niches for Cancer Immune Therapy
Lee, S. (PI), Phan, T. (PI), Croucher, P. (CoI), Jin, D. (CoI), Pajic, M. (CoI), Smyth, M. J. (CoI), Thomas, D. (CoI) & Timpson, P. (CoI)
1/06/21 → 31/12/26
Project: Research
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Understanding and controlling thrombus formation
Gardiner, E. (PI), Andrews, R. (CoI), Lee, S. (CoI) & Mangin, P. H. (CoI)
1/01/21 → 31/12/24
Project: Research
Prizes
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2014 ANSTO Eureka Prize for Innovative Use of Technology
Lee, S. (Recipient), 2014
Prize: Prizes and Awards