Research output per year
Research output per year
Personal profile
Biography
Tamás Fischer is an Associate Professor at The John Curtin School of Medical Research (JCSMR) at The Australian National University. He completed his PhD studies in 2005 at the University of Heidelberg, Germany, working on the nuclear export of mRNA and its coupling to transcription. Following his PhD, he was awarded a postdoctoral fellowship in epigenetics and chromatin biology at the National Cancer Institute (NCI, NIH) in the USA. He returned to Germany in 2010 to establish his own independent research group at the University of Heidelberg Biochemistry Center. He has recently moved his laboratory to Canberra, Australia to join the Department of Genome Sciences at JCSMR.
Qualifications
PhD
Research Interests
The major research focus in the Fischer lab is to understand the connection between chromatin structure, pervasive transcription and RNA surveillance, and their influence on genomic stability and disease development, especially in cancer and aging-related diseases. In addition, the lab is pursuing synthetic biology approaches to develop early detection and novel treatment methods in cancer.
Research student supervision
- Registered to supervise
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Collaborations and top research areas from the last five years
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STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis
Shen, Y., Wang, X., Liu, Y., Singhal, M., Gürkaşlar, C., Valls, A. F., Lei, Y., Hu, W., Schermann, G., Adler, H., Yu, F. X., Fischer, T., Zhu, Y., Augustin, H. G., Schmidt, T. & De Almodóvar, C. R., 7 Dec 2021, In: Science Signaling. 14, 712, abj8393.Research output: Contribution to journal › Article › peer-review
110 Citations (Scopus) -
The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain
Dobrev, N., Ahmed, Y. L., Sivadas, A., Soni, K., Fischer, T. & Sinning, I., 1 Dec 2021, In: Nature Communications. 12, 1, 3456.Research output: Contribution to journal › Article › peer-review
Open Access24 Citations (Scopus) -
PGRMC1 effects on metabolism, genomic mutation and CpG methylation imply crucial roles in animal biology and disease
Thejer, B. M., Adhikary, P. P., Teakel, S. L., Fang, J., Weston, P. A., Gurusinghe, S., Anwer, A. G., Gosnell, M., Jazayeri, J. A., Ludescher, M., Gray, L. A., Pawlak, M., Wallace, R. H., Pant, S. D., Wong, M., Fischer, T., New, E. J., Fehm, T. N., Neubauer, H. & Goldys, E. M. & 3 others, , 15 Apr 2020, In: BMC Molecular and Cell Biology. 21, 1, 26.Research output: Contribution to journal › Article › peer-review
Open Access20 Citations (Scopus) -
Revealing the Superpowers of PrimPol: rescuing replicating microsatellites
Reid, J. E. A. & Fischer, T., 1 Feb 2019, In: EMBO Journal. 38, 3, e101298.Research output: Contribution to journal › Comment/debate › peer-review
Open Access2 Citations (Scopus) -
The lipid-droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4
Jebessa, Z. H., Shanmukha, K. D., Dewenter, M., Lehmann, L. H., Xu, C., Schreiter, F., Siede, D., Gong, X. M., Worst, B. C., Federico, G., Sauer, S. W., Fischer, T., Wechselberger, L., Müller, O. J., Sossalla, S., Dieterich, C., Most, P., Gröne, H. J., Moro, C. & Oberer, M. & 4 others, , 1 Nov 2019, In: Nature Metabolism. 1, 11, p. 1157-1167 11 p.Research output: Contribution to journal › Article › peer-review
Open Access59 Citations (Scopus)
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On-target mRNA technology using self-splicing introns
Fischer, T. (PI) & Preiss, T. (CoI)
1/06/26 → 1/06/29
Project: Research
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Breaking the monopoly: A Parallel Route for mRNA Export
Fischer, T. (PI), Burr, M. (CoI) & Hinde, E. (CoI)
20/03/26 → 19/03/30
Project: Research
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Innovative design and synthesis approaches for therapeutic coding and noncoding RNA
Preiss, T. (PI), Ataide, S. (CoI), Burr, M. (CoI), Cohen, S. (CoI), Fischer, T. (CoI), Ginn, S. (CoI) & Thordarson, P. (CoI)
2/02/26 → 15/02/28
Project: Research
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Nuclear RNA surveillance and its connection to splicing quality control
Fischer, T. (PI), Horvath, A. (CoI) & Sinning, I. (CoI)
1/01/24 → 31/12/26
Project: Research
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NHMRC 2024 Equipment Grant - Equipment for preclinical mRNA production and testing
Preiss, T. (PI), Burr, M. (CoI), Fischer, T. (CoI), Gardiner, E. (CoI), George, A. (CoI), Palmer, S. (CoI) & Perriman, A. (CoI)
27/08/25 → 31/12/25
Project: Research