Research output per year
Research output per year
Personal profile
Qualifications
BSc (Hons) Uni Melb. PhD (Uni Melb)
Research Interests
Understanding the genetic and molecular causes of lupus and other immune diseases.
Autoimmune diseases affect roughly 5% of the population with an even higher incidence in Indigenous populations. Despite the plethora of genetic variant information yielded by next generation sequencing data from patients, autoimmune diseases are still poorly characterised at both the genetic and molecular pathway levels making effective targeted treatments near impossible. My research looks at improving identification of potential disease-causing genetic variants in individual patients, understanding the molecular impacts these variants have on protein function and illuminating the biochemical pathways impacted so that we can tailor precision therapies to more effectively treat patients and improve health outcomes.
Please contact us to discuss current research projects
Research student supervision
- Registered to supervise
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Collaborations and top research areas from the last five years
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DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency
Turnbull, C., Bones, J., Stanley, M., Medhavy, A., Wang, H., Lorenzo, A. M. D., Cappello, J., Shanmuganandam, S., Pandey, A., Seneviratne, S., Brown, G. J., Meng, X., Fulcher, D., Burgio, G., Man, S. M., de Lucas Collantes, C., Gasior, M., Granados, E. L., Martin, P., Jiang, S. H., & 6 others, Dec 2023, In: Science advances. 9, 49, eadi9566.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
A protocol to evaluate immunoglobulin deposits in mouse glomeruli
Nambadan, S. B., Stanley, M., Zhang, Y., Athanasopoulos, V. & Jiang, S. H., 17 Jun 2022, In: STAR Protocols. 3, 2, 101375.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Immunophenotyping identifies distinct cellular signatures for systemic lupus erythematosus and lupus nephritis
Aw, Y. T. V., Whiley, P. J., Lorenzo, A. M., Lea-Henry, T., Shanmuganandam, S., Stanley, M., Babu, S. N., Athanasopoulos, V., Cappello, J., Ellyard, J. I., Cook, M., Vinuesa, C., Walters, G., Fulcher, D. A. & Jiang, S. H., 23 Nov 2022, In: Rheumatology and Autoimmunity. 3, 1, p. 15-25 11 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
TLR7 gain-of-function genetic variation causes human lupus
Brown, G. J., Cañete, P. F., Wang, H., Medhavy, A., Bones, J., Roco, J. A., He, Y., Qin, Y., Cappello, J., Ellyard, J. I., Bassett, K., Shen, Q., Burgio, G., Zhang, Y., Turnbull, C., Meng, X., Wu, P., Cho, E., Miosge, L. A., Andrews, T. D., & 24 others, 12 May 2022, In: Nature. 605, 7909, p. 349-356 8 p.Research output: Contribution to journal › Article › peer-review
Open Access231 Citations (Scopus) -
A point mutation in IKAROS ZF1 causes a B cell deficiency in mice
Boast, B., Miosge, L. A., Kuehn, H. S., Cho, V., Athanasopoulos, V., McNamara, H. A., Sontani, Y., Mei, Y., Howard, D., Sutton, H. J., Omari, S. A., Yu, Z., Nasreen, M., Daniel Andrews, T., Cockburn, I. A., Goodnow, C. C., Rosenzweig, S. D. & Enders, A., 1 Apr 2021, In: Journal of Immunology. 206, 7, p. 1505-1514 10 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus)
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Improving genetic diagnosis of autoimmune and autoinflammatory disease through an integrated multi-omics approach
Jiang, S., Alexander, S., Andrews, D., Ascher, D., Athanasopoulos, V., Chakera, A., Day, J., Morrisroe, K., Nikpour, M., Randall, K., Wicks, I. & Yu, D.
1/06/23 → 31/05/27
Project: Research
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Personalised medicine in the treatment of complex autoimmunity and autoinflammatory disease
Jiang, S., Andrews, D., Athanasopoulos, V., Chakera, A., Morrisroe, K., Randall, K., Rogers, N. & Walters, G.
1/02/23 → 31/01/27
Project: Research
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TLR7 mutations cause human monogenic lupus: Understanding mechanism to illuminate therapy.
1/01/20 → 31/12/22
Project: Research
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Cell-specific regulation of the microRNA/RNAi pathway
Athanasopoulos, V. & Chong, M. M. W.
1/01/12 → 31/12/17
Project: Research