Personal profile
Qualifications
BSc (Hons) Uni Melb. PhD (Uni Melb)
Research Interests
Understanding the genetic and molecular causes of lupus and other immune diseases.
Autoimmune diseases affect roughly 5% of the population with an even higher incidence in Indigenous populations. Despite the plethora of genetic variant information yielded by next generation sequencing data from patients, autoimmune diseases are still poorly characterised at both the genetic and molecular pathway levels making effective targeted treatments near impossible. My research looks at improving identification of potential disease-causing genetic variants in individual patients, understanding the molecular impacts these variants have on protein function and illuminating the biochemical pathways impacted so that we can tailor precision therapies to more effectively treat patients and improve health outcomes.
Please contact us to discuss current research projects
Research student supervision
- Registered to supervise
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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A TNIP1-driven systemic autoimmune disorder with elevated IgG4
Medhavy, A., Athanasopoulos, V., Bassett, K., He, Y., Stanley, M., Enosi Tuipulotu, D., Cappello, J., Brown, G. J., Gonzalez-Figueroa, P., Turnbull, C., Shanmuganandam, S., Tummala, P., Hart, G., Lea-Henry, T., Wang, H., Nambadan, S., Shen, Q., Roco, J. A., Burgio, G. & Wu, P. & 11 others, , Sept 2024, In: Nature Immunology. 25, 9, p. 1678-1691 14 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity
Zhang, Y., Morris, R., Brown, G. J., Lorenzo, A. M. D., Meng, X., Kershaw, N. J., Kiridena, P., Burgio, G., Gross, S., Cappello, J. Y., Shen, Q., Wang, H., Turnbull, C., Lea-Henry, T., Stanley, M., Yu, Z., Ballard, F. D., Chuah, A., Lee, J. C. & Hatch, A. M. & 15 others, , 28 Feb 2024, In: Journal of Experimental Medicine. 221, 4, 26 p., e20221080.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency
Turnbull, C., Bones, J., Stanley, M., Medhavy, A., Wang, H., Lorenzo, A. M. D., Cappello, J., Shanmuganandam, S., Pandey, A., Seneviratne, S., Brown, G. J., Meng, X., Fulcher, D., Burgio, G., Man, S. M., de Lucas Collantes, C., Gasior, M., Granados, E. L., Martin, P. & Jiang, S. H. & 6 others, , Dec 2023, In: Science advances. 9, 49, eadi9566.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
A protocol to evaluate immunoglobulin deposits in mouse glomeruli
Nambadan, S. B., Stanley, M., Zhang, Y., Athanasopoulos, V. & Jiang, S. H., 17 Jun 2022, In: STAR Protocols. 3, 2, 101375.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Immunophenotyping identifies distinct cellular signatures for systemic lupus erythematosus and lupus nephritis
Aw, Y. T. V., Whiley, P. J., Lorenzo, A. M., Lea-Henry, T., Shanmuganandam, S., Stanley, M., Babu, S. N., Athanasopoulos, V., Cappello, J., Ellyard, J. I., Cook, M., Vinuesa, C., Walters, G., Fulcher, D. A. & Jiang, S. H., 23 Nov 2022, In: Rheumatology and Autoimmunity. 3, 1, p. 15-25 11 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus)
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Resolving how A20 variants drive toll-like receptor mediated kidney disease in Indigenous Australians
Athanasopoulos, V. (PI), Downes, M. (CoI), Hermes, A. (CoI), Jiang, S. (CoI), Lea-Henry, T. (CoI), McMorran, B. (CoI) & Nolan, C. (CoI)
1/01/26 → 31/12/29
Project: Research
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Improving genetic diagnosis of autoimmune and autoinflammatory disease through an integrated multi-omics approach
Jiang, S. (PI), Alexander, S. (CoI), Alexander, S. (CoI), Andrews, D. (CoI), Ascher, D. (CoI), Ascher, D. (CoI), Athanasopoulos, V. (CoI), Chakera, A. (CoI), Day, J. (CoI), Morrisroe, K. (CoI), Nikpour, M. (CoI), Randall, K. (CoI), Wicks, I. (CoI) & Yu, D. (CoI)
1/06/23 → 31/05/27
Project: Research
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Personalised medicine in the treatment of complex autoimmunity and autoinflammatory disease
Jiang, S. (PI), Andrews, D. (CoI), Athanasopoulos, V. (CoI), Chakera, A. (CoI), Morrisroe, K. (CoI), Randall, K. (CoI), Rogers, N. (CoI), Rogers, N. (CoI) & Walters, G. (CoI)
1/02/23 → 31/01/27
Project: Research
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TLR7 mutations cause human monogenic lupus: Understanding mechanism to illuminate therapy.
Athanasopoulos, V. (PI)
1/01/20 → 31/12/22
Project: Research
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Cell-specific regulation of the microRNA/RNAi pathway
Athanasopoulos, V. (PI) & Chong, M. M. W. (PI)
1/01/12 → 31/12/17
Project: Research