3D Structure determination of biomacromolecular assemblies from sparse data

This application is for the development of a highly cost-efficient bioinformatic approach to determine the three-dimensional (3D) structure of proteins and protein-protein complexes from a minimal set of experimental data. The goal is to understand the delicately balanced dynamic interactions between different molecules which form the basis of life and also offer key points for pharmaceutical intervention. The research will access innovative tools currently being developed in Australia and overseas that are designed to determine the 3D structures of biomacromolecular assemblies, assess their functional properties and screen inhibitor libraries using novel strategies.