A radical approach to unnatural amino acids and peptide-based antibiotics

Unnatural amino acids are important motifs for the development of novel therapeutics, including the growing class of peptide-based drugs. This project aims to shift the paradigm of peptide drug discovery by developing a new synthetic approach to valuable amino acid derivatives and their rapid incorporation into peptide analogues, including promising new antibiotic candidates. This interdisciplinary project seeks to enhance knowledge in the chemical and biological sciences and build scientific capacity to address the global rise of antimicrobial resistance. It is anticipated that this project will provide direct health and economic benefits by establishing a powerful platform for peptide drug design.