A20 variants contribute to endemic kidney disease in Tiwi Islanders

Kidney disease is endemic amongst the Tiwi Islanders with the highest reported rates worldwide. It is thought that 60% of this risk comes from genetics. We have identified six gene variants in a gene likely to be important in controlling progression of kidney disease. These variants impair the ability of the gene to prevent kidney disease and offers a novel treatment target for the Tiwi Islanders.