Advancing health equity for Indigenous Australians through pharmacogenomics: building an end-to-end discovery pipeline

About 80% of efficacy and safety of medical drug interventions depend on genetic variation impacting drug metabolism and function. Indigenous Australians have so far been excluded from scalable drug gene studies as well as drug scrutiny in clinical trials and post-marketing safety surveillance. We set out to lay foundations for rational drug use by determination and functional characterization of known and novel drug gene variants in diverse genomes of Indigenous populations across Australia.