Backbone Editing Strategies: Underutilised Tools for Peptide Drug Discovery

Emerging diseases and growing resistance to current treatments highlight the need for new therapeutic molecules to sustain Australian health and economic well-being. Medicinal chemists develop and deploy effective medicines by applying chemical tools to alter the structure and function of promising candidate molecules. This project will explore new technologies to fine-tune underexplored classes of therapeutic molecules, enabling the evaluation of molecules which are inaccessible using existing techniques. Importantly, the proposed technologies will increase the efficiency of production and reduce the reliance on toxic reagents through the innovative application of electrochemistry'an environmentally-conscious method in which electricity, rather than a toxic chemical, is used to produce a chemical reaction. These technologies offer vast commercial potential for Australia's growing biotec