Beyond the genome: unravelling the intricacies of epigenetic regulation using the honey bee model

    Project: Research

    Project Details

    Description

    Epigenetic modifications of the genome, such as DNA methylation are key regulators of development, tissue-specificity and genomic responses to environmental influence including stress, diet and toxins. Abnormalities in epigenetic mechanisms lead to diseases such as cancer, obesity and brain disorders. We are using the diet-controlled phenotypic dichotomy of queens and workers in honey bees to understand how contrasting organismal outputs are generated from the same genome by differential methylation of selected genes. This project will shed light on the role of genome-wide modifications of epigenetic marks in developmental polymorphism, in brain plasticity and in trans-generational effects
    StatusFinished
    Effective start/end date1/01/1231/12/14

    Funding

    • Australian Research Council (ARC): A$270,000.00

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