Chemoenzymatic Routes to Novel Dendritic Architectures Suitable for Pharmaceutical Applications

  • Banwell, Martin (PI)

    Project: Research

    Project Details

    Description

    Dendritic molecules incorporating multiple copies of a particular functional group on their periphery allow for attachment of drug-like molecules at each of these sites. The resulting conjugates often have vastly superior therapeutic properties relative to the original single drug molecule. This phenomenon is now revolutionizing drug design. Developments in this area are limited by the range of dendritic molecules currently available. Thus, lack of variation in the three-dimensional architecture and the functionality available at the periphery of such constructs is a serious deficiency. This proposal seeks to redress this through the application of novel chemoenzymatic methods developed by the applicant.
    StatusFinished
    Effective start/end date19/03/0418/03/07

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