Development of a synthetic route to sterically hindered indoles

The intention is to identify/provide new, more efficient and flexible as all well as more economical methods for the synthesis of key classes of chemical building blocks that can be exploited in the assembly of a range of drugs and drug candidates used for the treatment of a range of medical conditions. Benefits would accrue from both the simpler nature of the starting materials to be used and the high purity of the products obtained DIRECTLY from the pivotal reactions (and thus avoiding the need to resort to tedious and costly purification processes). A key focus of the project/research activities will be deploying the palladium catalysed Ullmann cross-coupling and Raney-cobalt catalysed reductive cyclisation methodologies. As a prelude to undertaking the experimental aspects of the research program a comprehensive review of the current chemical literature will be undertaken and an article suitable for publication in a high-end chemical journal will be produced