Dissecting a novel RNA-histone variant interaction and its role in splicing

    Project: Research

    Project Details

    Description

    This project aims to define the molecular details of how a unique chromatin component, histone H2A.B, binds RNA and influences RNA splicing. This is unprecedented for histones, which are typically associated with DNA and transcriptional regulation. Over 90% of human genes are estimated to be alternatively spliced, and this helps explain how complex organisms develop from a limited set of genes. Yet, how alternative splicing decisions are made is still unclear. The intended outcome of this study is to reveal new links between chromatin, RNA splicing, and gene expression regulation to help explain how multicellular organisms have evolved. This will also lay foundations for developing new genetic technologies and understanding human disease.
    StatusFinished
    Effective start/end date1/01/1730/06/22

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