Elucidating the organisational principals of genome architecture: the role of histone variants and architectural chromatin binding proteins

It has been more than a decade since the human genome has been completely sequenced but how this genomic information is selectively utilizedto direct gene expression that is unique to each of the approximate 200 different cell types of the human body remains to be elucidated. We havenew data to suggest that it is how our genome is packaged into a variety of different and dynamic 3-dimensional structures in a cell thatdetermines cell-type specific programs of gene expression.