Enhancing extracellular vesicle-cell interactions with chiral recognition

This project aims to understand how the chiral profile (handedness) of extracellular vesicles (EVs) determines their destination and to develop methods to alter their “address label.” By characterizing the chirality of EVs using newly developed analytical tools, the project will advance knowledge of EV biology by elucidating the impact of chirality on their structural properties and cellular interactions, paving the way for more precise and effective design of EV-based therapeutics. Expected outcomes include a universal analytical pipeline for studying the chirality of EVs, with the potential to deliver valuable intellectual property of commercial interest, offering potential economic benefits to the pharmaceutical industry in Australia.