Experimental and Computational Investigations into Enantioselective Domino Sequences

This research aims to develop short enantioselective chemical syntheses of structurally complex, biologically active, natural products. We aim to achieve this goal by devising new, efficient synthesis protocols based on domino reactions, spectacular chemical transformations which allow the rapid elaboration of complex molecular architectures from simple precursors. The powerful, enabling technology developed throughout this project is significant since it is widely applicable within the field of chemical synthesis. Our expected outcomes include a demonstration of the applicability of our new methods for the preparation of specific, challenging target structures along many analogues for biological evaluation.