Project Details
Description
The NODk mouse model is protected from type 1 diabetes through being congenic for a low risk MHC alelle. We are studying two sub-strains of the NODk mouse, one prone (O-NODk) and one resistant (RF-NODk) to developing type 2 diabetes on a high fat diet.
We aim to determine:
1) The mechanisms of the increased islet β-cell susceptibility to failure in O-NODk compared to RF-NODk mice
2) The genetic basis of of the increased susceptibility to islet β-cell failure in O-NODk compared to RF-NODk mice
Status | Finished |
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Effective start/end date | 1/01/18 → 31/12/18 |
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