Guiding principles and guardrails for smallish genetic association studies

This project aims to investigate deep connections between genetic structure (population genetic processes, linkage disequilibrium, population structure) and the ability to statistically detect genetic variants responsible for variation in traits. This project expects to generate new knowledge in the areas of statistics, mathematics and biology through an innovative, multidisciplinary approach that synthesises and extends foundational disciplinary results. Expected outcomes of this project include well-cited publications, principles and methodology that underpin future genetic association studies by supplying a framework for interpreting results. The should provide significant benefits by reducing false conclusions and their incumbent costs.