How exercise prevents obesity-related hepatocellular carcinoma: insights for chemoprevention of liver cancer

Nonalcoholic fatty liver associated with obesity and diabetes is common and an important contributor to rapidly increasing rates of liver cancer. The applicants have established a model of obesity, diabetes and fatty liver in mice with accelerated onset liver cancer. Providing an exercise wheel prevented this early-onset of liver cancer. This proposal will clarify how exercise prevents liver cancer, so the protective mechanisms can be harnessed in the form of drugs to prevent liver cancer.