MicroRNA control of gene expression and development in plants

MicroRNAs (miRNAs) are a newly discovered class of genes that act as molecular switches controlling development in plants and animals. We have identified the first plant miRNA mutant that has defects in seed, fruit, stem and leaf development. In combination with genomic and molecular approaches, we aim to elucidate to what extent miRNA-mediated developmental programs work via conceptually novel regulatory mechanisms, integrating epigenetic mechanisms and hormone signals to control gene expression. The information will not only increase our knowledge on how miRNAs control an organism s form and function, but give insight on how manipulation of miRNAs may introduce favourable traits into crop species.