Modelling human brain development with stem cells and biomaterials

  • Nisbet, David (PI)
  • Parish, Clare (PI)

    Project: Research

    Project Details

    Description

    With limited resources to directly study and advance our understanding of human neural development, thisproposal will establish models of 4 key stages. Employing innovative, interdisciplinary approaches, biomaterialswill be fabricated to provide structural and chemical support for human stem cells during: (i) neural induction, (ii)specification into neuronal progenitor subpopulations, (iii) neuronal maturation and integration into complex neuralnetworks as well as, (iv) the organisation of neurons into larger 3-dimensional brain structures, namely folding ofthe human cortex. Further, biomaterials developed here have commercialisation potential, targeted atstandardizing the culturing of human stem cells to defined neural populations.
    StatusFinished
    Effective start/end date20/05/2022/08/21

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