Modifying the B cell response to Plasmodium to make better vaccines

All our current vaccines are based on the development of protective antibody responses. However existing malaria vaccines (and vaccine candidates) are only able to induce very transient antibody responses. In this project we test the idea that this is because existing vaccines stimulate a burst of antibody producing cells, but fail to induce the immunological memory required for sustained effectiveness. We will then examine ways we can induce better long-term protection