Project Details
Description
3D structure underpins protein function but remains difficult to elucidate in many cases. This application is for the development of new nuclear magnetic resonance (NMR) and cell-free protein production technologies to characterize the structure of the functionally important parts of proteins. The project encompasses development of a new method for protein structure determination using lanthanide-labelling, chemical synthesis of lanthanide-binding tags, high-throughput cell-free protein production, and applications to 3D structure determinations of large (>100 kDa) protein assemblies and of protein-ligand complexes. Targets include the dengue virus NS2B/NS3 protease. The project aims for immediate impact in pharmaceutical industries.
Status | Finished |
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Effective start/end date | 1/01/08 → 31/12/10 |
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