Non-Canonical Amino Acids for Protein Analysis in vitro and in Cells

Proteins are large complex molecules essential for all life processes. They play many critical roles, including signalling to other molecules, providing structural support in cells, and functioning as key components in molecular machines that maintain and replicate genetic information. Whether embedded in membranes or floating in solution, proteins have a defined structure, but it is their motion which often dictates their function.This project aims to develop new approaches to observe structure changes and dynamics of proteins in their physiological environment, such as in cells, using inconspicuous reporter probes.By leveraging innovative biochemistry, modern spectroscopy methods and high-performance computing, we aim to gain detailed knowledge on protein-ligand interactions and the motion of important disease-related proteins. This knowledge will help with the design of new pharmac