Protein Structure and Dynamics by Electron/Nuclear Paramagnetic Resonance

Pharmaceutical research routinely employs nuclear magnetic resonance (NMR) spectroscopy to verify the binding of drugs to their intended targets. This project aims to develop better magnetic resonance techniques to accelerate the early stages of drug discovery. It will combine innovative biochemistry, modern magnetic resonance spectroscopy, in particular electron paramagnetic resonance (EPR), and high-performance computing to accelerate the detection of drug candidates with their target, both inside and outside cells. Results will inform medicinal chemists on the activity and possible side effects of drug candidates and how they can be improved. This project will support Australias fast growing biotechnology sector by accelerating the rate with which these companies can secure intellectual property and help to establish a sovereign capacity in the development and manufacture of drug therapies.