Refinement and delivery of synthetic compounds that specifically alter muscle contraction

  • Dulhunty, Angela (PI)
  • Casarotto, Marco (CoI)
  • Easton, Chris (CoI)

    Project: Research

    Project Details

    Description

    The aim of the project is refine synthetic compounds that specifically and reversibly activate or inhibit ryanodine receptor calcium release channels, and will thus increase or reduce the force developed by skeletal muscle and the heart. The compounds will be useful in biomedical and veterinary sciences and in the livestock industry. Some of the compounds that are not effective on mammalian ryandine receptor isoforms might interact with insect channels and provide a template for a new class of insecticides. The compounds are based on naturally occurring peptides which specifically modulate mammalian calcium channels.
    StatusFinished
    Effective start/end date1/01/061/08/07

    Funding

    • Australian Research Council (ARC): A$142,500.00
    • Biotron Ltd: A$60,000.00

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