Resolving how A20 variants drive toll-like receptor mediated kidney disease in Indigenous Australians

Indigenous Australians of the Tiwi Islands have excessive rates of kidney disease thought to be partly driven by genetics. Inflammation is a key contributor of kidney disease regardless of the cause. We generated an animal model which has a mutation in an anti-inflammation gene, that worsens kidney disease. This project will investigate how inflammation, combined with autoimmune disease, diet and infection, contribute to worse kidney outcomes, with the aim of developing specific treatments.