Ribosome biogenesis and disease

Ribosomes are macromolecular machines that synthesise all cellular proteins and their catalytic core, the ribosomal RNAs, are synthesised from hundreds of ribosomal genes in a sub-nuclear body termed the nucleolus. This application continues my work on developing drugs that target the nucleolus for cancer therapies and ribosomopathies and investigate new non-ribosomal functions of the nucleolus that we believe are important for normal cellular development and which are dysregulated in disease.