Scalable purification of viral vectors by metal affinity chromatography

This project aims to advance manufacturing practices for viral vaccines by improving product purity using affinitychromatography a simple and cost-effective technique. We will use ANU-developed technology to create taggedviruses suitable for chromatography purification, allowing testing of virus compatibility with the technique andvalidation of analytical tools for vaccine yield and purity. We will then collaborate with Australian partner, SementisLtd, to prove the concept with the Sementis Copenhagen Vector (SCV) vaccine platform. The study will progresstag-and-purify technology to an integrated manufacturing solution (TRL3 to 4), and work towards the goal ofenhancing sovereign capabilities.