Targeting cancer metabolism to reduce metastases

Cancer that spreads is the major cause of death in cancer patients. We have a drug with very low toxicity that changes how cancer cells use their glucose (metabolism) which, in mouse cancers, can also reduce the spread of cancer cells. We will expand these studies into human breast cancer cells to see if they respond the same way. By looking at over 20 cancer cell types, we will define which cancers respond to this drug, paving the way for clinical trials in patients who will benefit.