Targeting RNA Polymerase I To Treat Cancer

    Project: Research

    Project Details

    Description

    An elevated level of ribosomal RNA (rRNA) production supports the uncontrolled growth of cancer cells and as a result they become "addicted" to abnormal levels of rRNA. Consequently, cancer cells become more sensitive to drugs that target rRNA production. This application explores the development and use of 2nd-generation inhibitors of the enzyme that synthesizes rRNA (Pol I) for the treatment of hematological and solid cancers.
    StatusFinished
    Effective start/end date1/01/1931/12/22

    Funding

    • National Health and Medical Research Council (NHMRC): A$1,206,043.00

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