The role of gamma glutamyl cyclotransferase in glutathione homeostasis

The aim of this study is to understand the structure and function of gamma-glutamyl cyclotransferase (GGCT) and its role in glutathione homeostasis. Glutathione is essential for life and serves multiple biological functions including acting as a cofactor in redox reactions, and aiding in the detoxification and excretion of xenobiotics. The investigations will achieve several outcomes. (1) An understanding of the GGCT active site and the reaction mechanism; (2) Identification of GGCT inhibitors with potential use in therapy; (3) A greater understanding of the factors regulating glutathione synthesis and turnover; (4) Knowledge of the localization of GGCT in tissues and cells.