The role of T cell derived interferon gamma in lupus associated anxiety and depression

  • Sweet, Rebecca (PI)

    Project: Research

    Project Details

    Description

    Mental illnesses have been associated with immune responses. One well-documented example of this is the anxiety and depression found in Systemic Lupus Erythematosus (SLE) patients, referred to as autoimmunity associated behavioral syndrome (AABS) in the MRL/lpr and NZB/W mouse models of SLE. Although AABS has been characterized in these mouse models, underlying molecular mechanisms remain unknown due to the burden of backcrossing genetic deficiencies, from the C57BL/6 (B6) strain, onto these complex strains. The study of AABS on a B6 derived model of SLE would enable efficient study of required factors. We propose to study AABS in sanroque mice, a T cell driven B6 derived model of SLE.
    StatusFinished
    Effective start/end date1/01/1323/10/16

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