Project Details
Description
Mental illnesses have been associated with immune responses. One well-documented example of this is the anxiety and depression found in Systemic Lupus Erythematosus (SLE) patients, referred to as autoimmunity associated behavioral syndrome (AABS) in the MRL/lpr and NZB/W mouse models of SLE. Although AABS has been characterized in these mouse models, underlying molecular mechanisms remain unknown due to the burden of backcrossing genetic deficiencies, from the C57BL/6 (B6) strain, onto these complex strains. The study of AABS on a B6 derived model of SLE would enable efficient study of required factors. We propose to study AABS in sanroque mice, a T cell driven B6 derived model of SLE.
Status | Finished |
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Effective start/end date | 1/01/13 → 23/10/16 |
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