The Role of the Ttyh1 Protein in Cell Activation

  • Campbell, Hugh (PI)
  • Crouch, Michael (CoI)

    Project: Research

    Project Details

    Description

    We have cloned TTYH1, a human homologue of the Drosophila melanogaster tweety gene. The mouse gene has also been identified. The predicted structure of the protein is a membrane protein with 5 transmembrane domains. We have also expressed a GFP-tagged fusion protein in mouse fibroblasts. Confocal microscopy indicates that this protein is likely to be a novel adhesion molecule, with a cellular distribution characteristic of molecules such as integrins. We aim to determine the function of Ttyh1, its interacting intra- and extra-cellular proteins and to assess its candidature as a molecule of importance in cell migration and adhesion.
    StatusFinished
    Effective start/end date1/01/0331/12/07

    Funding

    • Australian Research Council (ARC): A$84,099.00
    • TGR Biosciences Pty Ltd: A$15,000.00

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