Therapeutic targeting of ribosome biogenesis in cancer and ribosomopathies

    Project: Research

    Project Details

    Description

    Principal Research Fellowship (PRF) - This project builds on my international leadership in understanding the role and regulation of ribosome biogenesis in human health and disease. I will use integrated cell & molecular biology, proteomics, and genetics/genomics approaches to uncover the molecular mechanisms governing the loss of normal control of ribosome biogenesis in cancer and ribosomopathies, and my expertise in drug development to translate findings into treatment paradigms for patients suffering from disease associated with ribosome dysfunction. I will develop 2nd generation Pol I inhibitors with improved selectivity and activity; continue to drive a national program of research, focusing on developing new treatments for a group of genetic diseases associated with mutations in ribosome components called ribosomopathies; and expand my cancer drug discovery research to target multiple components controlling ribosome biogenesis and nucleolar function.
    StatusFinished
    Effective start/end date1/01/1731/12/21

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