Type I interferon signalling in bacterial infection

Infectious diseases are a leading cause of death in Australia. Activation of disease-fighting inflammasomes sets in motion rapid immunedefenses against pathogens. In this project, we explore how cell-cell communication molecules known as type I interferons communicate withinflammasomes to achieve the best outcome in the body in response to deadly bacterial infection. Understanding how these signals communicatewith one another could reveal new ways to fight infectious diseases.