Ultrafast magic angle spinning solid-state NMR capability

This Project is for structure investigations of proteins in the solid state by nuclear magnetic resonance (NMR) spectroscopy. Many proteins, such as amyloids and flexible proteins, cannot be studied by X-ray crystallography, solution NMR spectroscopy or cryoelectron microscopy, because they cannot be crystallized or are not sufficiently soluble or structurally too heterogeneous. This Project will extend the capability of an existing 800 MHz NMR spectrometer to solid-state NMR. By offering ultrafast magic angle spinning speeds, the system aims to afford greatly enhanced sensitivity and multidimensional NMR spectra of protein systems not previously amenable to structural analysis by NMR spectroscopy or other techniques.