Understanding multidrug resistance: identifying the molecular basis of substrate and inhibitor transport by P-glycoprotein

  • O'Mara, Megan (PI)

    Project: Research

    Project Details

    Description

    Chemotherapy resistance causes 90% of cancer deaths and is commonly triggered by the increased activity of P-glycoprotein, which controls the cellular clearance of drugs. This project will determine how Pglycoproteinrecognises and transports drugs, essential knowledge for the design of anticancer agents thatcan stop chemotherapy resistance.
    StatusFinished
    Effective start/end date5/01/1230/06/16

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