1000 Quantifying multiple causes of death: A systematic review and audit of methods and practice

Saliu Balogun, Karen Bishop, James Eynstone-Hinkins, Melonie Martin, Margarita Moreno-Betancur, Chalapati Rao, Grace Joshy

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Background Mortality reporting and research are typically focused on a single underlying cause of death (UCoD) selected from multiple reported causes. The need to incorporate multiple causes of death (MCoD) in mortality statistics is now recognised internationally, but there is scant methodological work to guide analytical approaches. This review aims to identify and appraise current methods and practices used to analyse MCoD data. Methods The Web of Science, Medline, Pubmed and Scopus (from inception to December 2019) were queried. Studies reporting MCoD alone or in comparison with single UCoD were included. The review is supplemented by qualitative interview with international experts. Results 3491 studies were identified; 141 full texts were included in the review. The measures usually estimated when analysing MCoD can be broadly categorised into descriptive measures (n=93 studies), measures of associations between diseases (n=46 studies) and advanced statistical methods (n=11 studies). Descriptive statistics commonly used include standardized ratio of multiple to underlying cause (SRMU) and mortality rates based on any mention of a disease. Approaches used to assess measures of associations between diseases include the Cause-of-Death Association Indicator (CDAI) and social network analysis. The advanced statistical methods include weighting MCoD and lethal defect-wear model of mortality. Audit results will be discussed. Conclusions This review provides a comprehensive and updated summary of methodological approaches used to analyse MCoD data. The merit of each analytical framework is discussed.
    Original languageEnglish
    Title of host publicationVolume 50, Issue Supplement_1, September 2021
    Place of PublicationOnline
    PublisherOxford Academic
    DOIs
    Publication statusPublished - 2021
    EventIEA WORLD CONGRESS OF EPIDEMIOLOGY 2021 - Online
    Duration: 1 Jan 2021 → …

    Publication series

    Name
    Number1
    Volume50

    Conference

    ConferenceIEA WORLD CONGRESS OF EPIDEMIOLOGY 2021
    Period1/01/21 → …
    OtherWed Sep 01 00:00:00 AEST 2021

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