TY - JOUR
T1 - 2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae)
AU - Auranwiwat, Chiramet
AU - Wongsomboon, Puttandon
AU - Thaima, Thanaphat
AU - Rattanajak, Roonglawan
AU - Kamchonwongpaisan, Sumalee
AU - Willis, Anthony C.
AU - Lie, Wilford
AU - Pyne, Stephen G.
AU - Limtharakul (née Ritthiwigrom), Thunwadee
N1 - Publisher Copyright:
© 2017
PY - 2017/7
Y1 - 2017/7
N2 - Three new 2-phenylnaphthalene derivatives, cherrevenaphthalenes A–C (1–3), and a new polyoxygenated cyclohexene derivative, (−)-uvaribonol F (4) together with six known compounds, 5–10, were isolated from the stem and root extracts of Uvaria cherrevensis (Annonaceae). The structures of all isolated compounds were elucidated by spectroscopic analysis. The structures of 3 and 4 were further confirmed by single crystal X-ray diffraction methods. Compound 2 exhibited modest antiplasmodial activity against the P. falciparum stains TM4/8.2 and K1CB1 with IC50 values of 18.8 ± 3.63 and 23.4 ± 4.08 μM, respectively, and weak cytotoxicity to a Vero cell line. Furthermore, compound 4 displayed cytotoxic activity against a KB cell line with an IC50 value of 22.1 ± 0.42 μM but was non-cytotoxic to the Vero cell line. Compound 5 revealed stronger cytotoxicity towards the KB cell line, with an IC50 value of 5.05 ± 0.86 μM and was nearly equally cytotoxic to the Vero cell line.
AB - Three new 2-phenylnaphthalene derivatives, cherrevenaphthalenes A–C (1–3), and a new polyoxygenated cyclohexene derivative, (−)-uvaribonol F (4) together with six known compounds, 5–10, were isolated from the stem and root extracts of Uvaria cherrevensis (Annonaceae). The structures of all isolated compounds were elucidated by spectroscopic analysis. The structures of 3 and 4 were further confirmed by single crystal X-ray diffraction methods. Compound 2 exhibited modest antiplasmodial activity against the P. falciparum stains TM4/8.2 and K1CB1 with IC50 values of 18.8 ± 3.63 and 23.4 ± 4.08 μM, respectively, and weak cytotoxicity to a Vero cell line. Furthermore, compound 4 displayed cytotoxic activity against a KB cell line with an IC50 value of 22.1 ± 0.42 μM but was non-cytotoxic to the Vero cell line. Compound 5 revealed stronger cytotoxicity towards the KB cell line, with an IC50 value of 5.05 ± 0.86 μM and was nearly equally cytotoxic to the Vero cell line.
KW - Annonaceae
KW - Antiplasmodial activity
KW - Cytotoxic activity
KW - Phenylnaphthalene
KW - Polyoxygenated cyclohexene
KW - Uvaria cherrevensis
UR - http://www.scopus.com/inward/record.url?scp=85020308911&partnerID=8YFLogxK
U2 - 10.1016/j.fitote.2017.06.002
DO - 10.1016/j.fitote.2017.06.002
M3 - Article
SN - 0367-326X
VL - 120
SP - 103
EP - 107
JO - Fitoterapia
JF - Fitoterapia
ER -