3-[123I]iodo-α-methyl-l-tyrosine transport and 4F2 antigen expression in human glioma cells

Karl J. Langen; Rosemarie Bonnie; Heinz Mühlensiepen; Paul Jansen; Stefan Bröer; Marcus Holschbach; Heinz H. Coenen

doi:10.1016/S0969-8051(00)00178-5

3-[¹²³I]iodo-α-methyl-l-tyrosine transport and 4F2 antigen expression in human glioma cells

Karl J. Langen, Rosemarie Bonnie, Heinz Mühlensiepen, Paul Jansen, Stefan Bröer, Marcus Holschbach, Heinz H. Coenen

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

3[¹²³I]iodo-α-methyl-L-tyrosine is a tracer of amino acid transport in brain tumors using single-photon emission-computed tomography and predominantly transported by amino acid transport system L. The 4F2 antigen has been identified to be linked to system L-like transport and is assumed to be a part of the transporter protein. We demonstrated that system L-mediated transport of IMT and 4F2 antigen expression are dependent on proliferation rate of human glioma cells and significantly correlated with each other.

Original language	English
Pages (from-to)	5-11
Number of pages	7
Journal	Nuclear Medicine and Biology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/S0969-8051(00)00178-5
Publication status	Published - 2001
Externally published	Yes

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10.1016/S0969-8051(00)00178-5

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title = "3-[123I]iodo-α-methyl-l-tyrosine transport and 4F2 antigen expression in human glioma cells",

abstract = "3[123I]iodo-α-methyl-L-tyrosine is a tracer of amino acid transport in brain tumors using single-photon emission-computed tomography and predominantly transported by amino acid transport system L. The 4F2 antigen has been identified to be linked to system L-like transport and is assumed to be a part of the transporter protein. We demonstrated that system L-mediated transport of IMT and 4F2 antigen expression are dependent on proliferation rate of human glioma cells and significantly correlated with each other.",

keywords = "3-[I]iodo-α-methyl-L-tyrosine, 4F2 antigen, Amino acids, Glioma cells, Proliferation",

author = "Langen, \{Karl J.\} and Rosemarie Bonnie and Heinz M{\"u}hlensiepen and Paul Jansen and Stefan Br{\"o}er and Marcus Holschbach and Coenen, \{Heinz H.\}",

year = "2001",

doi = "10.1016/S0969-8051(00)00178-5",

language = "English",

volume = "28",

pages = "5--11",

journal = "Nuclear Medicine and Biology",

issn = "0969-8051",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - 3-[123I]iodo-α-methyl-l-tyrosine transport and 4F2 antigen expression in human glioma cells

AU - Langen, Karl J.

AU - Bonnie, Rosemarie

AU - Mühlensiepen, Heinz

AU - Jansen, Paul

AU - Bröer, Stefan

AU - Holschbach, Marcus

AU - Coenen, Heinz H.

PY - 2001

Y1 - 2001

N2 - 3[123I]iodo-α-methyl-L-tyrosine is a tracer of amino acid transport in brain tumors using single-photon emission-computed tomography and predominantly transported by amino acid transport system L. The 4F2 antigen has been identified to be linked to system L-like transport and is assumed to be a part of the transporter protein. We demonstrated that system L-mediated transport of IMT and 4F2 antigen expression are dependent on proliferation rate of human glioma cells and significantly correlated with each other.

AB - 3[123I]iodo-α-methyl-L-tyrosine is a tracer of amino acid transport in brain tumors using single-photon emission-computed tomography and predominantly transported by amino acid transport system L. The 4F2 antigen has been identified to be linked to system L-like transport and is assumed to be a part of the transporter protein. We demonstrated that system L-mediated transport of IMT and 4F2 antigen expression are dependent on proliferation rate of human glioma cells and significantly correlated with each other.

KW - 3-[I]iodo-α-methyl-L-tyrosine

KW - 4F2 antigen

KW - Amino acids

KW - Glioma cells

KW - Proliferation

UR - https://www.scopus.com/pages/publications/0034746232

U2 - 10.1016/S0969-8051(00)00178-5

DO - 10.1016/S0969-8051(00)00178-5

M3 - Article

SN - 0969-8051

VL - 28

SP - 5

EP - 11

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

IS - 1

ER -

3-[¹²³I]iodo-α-methyl-l-tyrosine transport and 4F2 antigen expression in human glioma cells

Abstract

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