3D structure determination of a protein in living cells using paramagnetic NMR spectroscopy

Bin Bin Pan, Feng Yang, Yansheng Ye, Qiong Wu, Conggang Li, Thomas Huber, Xun Cheng Su*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    87 Citations (Scopus)

    Abstract

    Determining the three-dimensional structure of a protein in living cells remains particularly challenging. We demonstrated that the integration of site-specific tagging proteins and GPS-Rosetta calculations provides a fast and effective way of determining the structures of proteins in living cells, and in principle the interactions and dynamics of protein-ligand complexes.

    Original languageEnglish
    Pages (from-to)10237-10240
    Number of pages4
    JournalChemical Communications
    Volume52
    Issue number67
    DOIs
    Publication statusPublished - 2016

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